Cellular response to magnesium ion

Across TCGA patient cohorts, RNA activity of the Cellular response to magnesium ion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK3, ATP13A4, and PDCD4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to magnesium ion activity versus ANK3 in GBM (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ANK3 →	+1.348	+0.747	<.001	<.001	3	10
PDAC	ATP13A4 →	+0.737	+0.444	<.001	.001	3	7
UCEC	PDCD4 →	+0.620	+0.718	<.001	.002	3	6
GBM	LNX1 →	+0.872	+0.497	<.001	.001	3	6
GBM	SH3BGRL2 →	+0.760	+0.532	<.001	<.001	3	6
PDAC	PARM1 →	+0.466	+0.369	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071286 vs ANK3 — GBM

Explore this scatter interactively →