Cellular response to magnesium ion

Across TCGA cell cohorts, RNA activity of the Cellular response to magnesium ion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHAMP1, KIF1C, and STX1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHAMP1 grouped by Cellular response to magnesium ion-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CHAMP1 →	-0.633	-1.218	.002	<.001	3	4
LUNG_NSCLC_LUAD	KIF1C →	-0.674	-0.569	.003	.003	3	4
BLOOD_Leukemia	STX1A →	+2.418	+1.729	<.001	<.001	3	4
BLOOD_Leukemia	POLE →	-0.561	-0.986	.006	.002	3	4
BLOOD_Leukemia	TMEM185A →	-0.676	-0.879	.002	.006	3	4
BLOOD_Myeloma	NONO →	-0.957	-1.298	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHAMP1 by Cellular response to magnesium ion activity — BLOOD_Leukemia

Explore this box plot interactively →