Cellular response to lead ion

Across TCGA patient cohorts, RNA activity of the Cellular response to lead ion pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX21_S89, IPO11, and SNTB2_S222, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to lead ion activity versus DDX21_S89 in LUAD (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DDX21_S89 →	-0.595	-0.055	.009	.009	2	8
UCEC	IPO11 →	-0.173	-0.106	.003	.001	3	7
GBM	SNTB2_S222 →	+0.602	+0.087	<.001	<.001	3	6
GBM	DAB2_S723 →	+0.994	+0.115	<.001	<.001	3	6
UCEC	ESF1_S153 →	-0.836	-0.089	<.001	.001	2	7
LSCC	FANCI →	-0.458	-0.057	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071284 vs DDX21_S89 — LUAD

Explore this scatter interactively →