Cellular response to iron ion

Across TCGA patient cohorts, RNA activity of the Cellular response to iron ion pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE4DIP, MOGAT1, and TLE2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to iron ion activity versus PDE4DIP in HNSC (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PDE4DIP →	-0.569	-0.419	.001	.001	3	4
UCEC	MOGAT1 →	-1.302	-0.165	.002	.001	3	3
PDAC	TLE2 →	-0.398	-0.448	.004	.006	3	3
HNSC	YPEL1 →	-0.417	-0.466	<.001	<.001	3	3
HNSC	DCPS →	-0.508	-0.494	<.001	.002	3	3
HNSC	LCK →	-0.806	-0.394	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071281 vs PDE4DIP — HNSC

Explore this scatter interactively →