Cellular response to copper ion

Across TCGA patient cohorts, RNA activity of the Cellular response to copper ion pathway is significantly associated with the RNA expression of multiple genes, with the LIHC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT1E, MT1F, and MT1M, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to copper ion activity versus MT1E in LIHC (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MT1E →	+3.571	+0.110	<.001	<.001	3	33
THCA	MT1F →	+2.693	+0.082	<.001	<.001	3	30
TGCT	MT1M →	+3.089	+0.107	<.001	<.001	3	29
THCA	MT1G →	+4.489	+0.080	<.001	<.001	3	28
LIHC	MT1X →	+2.919	+0.110	<.001	<.001	3	27
LIHC	MT1A →	+2.513	+0.089	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071280 vs MT1E — LIHC

Explore this scatter interactively →