Cellular response to copper ion

Across TCGA cell cohorts, RNA activity of the Cellular response to copper ion pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSEN2, MICU3, and RDH11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSEN2 grouped by Cellular response to copper ion-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PSEN2 →	-1.085	-1.284	.001	.004	3	4
LUNG_NSCLC_LUAD	MICU3 →	+0.792	+0.764	.002	.005	3	4
UPPER_AERODIGESTIVE_TRACT	RDH11 →	-1.319	-1.598	.001	<.001	3	4
SOFT_TISSUE	B4GALT2 →	+0.831	+1.554	.001	<.001	3	4
KIDNEY	DMAC2L →	-0.865	-1.380	.001	.001	3	4
CNS	MPHOSPH6 →	-0.403	-0.726	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSEN2 by Cellular response to copper ion activity — LIVER

Explore this box plot interactively →