Cellular response to copper ion

Across TCGA cell cohorts, RNA activity of the Cellular response to copper ion pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOP14, CLUH, and PRNP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to copper ion activity versus NOP14 in STOMACH (Pearson r = -0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NOP14 →	-0.721	-0.967	.001	.004	3	7
LUNG_SCLC	CLUH →	-0.568	-0.806	.004	<.001	3	7
LIVER	PRNP →	+2.060	+1.949	.008	<.001	2	7
CNS	PCNX3 →	-0.466	-0.887	.001	.002	3	5
BLOOD_Myeloma	ZNF532 →	+2.081	+0.333	.005	.004	3	5
CNS	RNF123 →	-0.561	-1.232	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071280 vs NOP14 — STOMACH

Explore this scatter interactively →