Cellular response to copper ion

Across TCGA cell cohorts, RNA activity of the Cellular response to copper ion pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APP, PGD, and PRNP, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to copper ion activity versus APP in LUNG_NSCLC_LUAD (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	APP →	+1.444	+1.170	<.001	<.001	3	14
LUNG_NSCLC_LUSC	PGD →	-3.371	-1.541	.003	<.001	3	10
SOFT_TISSUE	PRNP →	+1.781	+1.756	<.001	<.001	3	10
LIVER	ITGB1 →	+2.174	+1.570	<.001	.003	3	10
LUNG_NSCLC_LUSC	UBE2K →	-1.864	-1.401	.002	.001	3	9
LUNG_NSCLC_LUSC	RANBP1 →	-1.680	-1.401	.005	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071280 vs APP — LUNG_NSCLC_LUAD

Explore this scatter interactively →