Cellular response to calcium ion

Across TCGA cell cohorts, RNA activity of the Cellular response to calcium ion pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UGP2, FBXL8, and ANKRD11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to calcium ion activity versus UGP2 in LIVER (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	UGP2 →	+0.864	+0.284	.001	.002	3	6
SKIN	FBXL8 →	+0.871	+0.225	<.001	<.001	3	5
SOFT_TISSUE	ANKRD11 →	+0.722	+0.349	<.001	.004	3	4
STOMACH	SIRT6 →	+0.817	+0.302	.001	.001	3	4
SOFT_TISSUE	CDK10 →	+1.187	+0.405	.007	.002	3	4
KIDNEY	ASPH →	+2.096	+0.319	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071277 vs UGP2 — LIVER

Explore this scatter interactively →