Cellular response to cadmium ion

Across TCGA patient cohorts, RNA activity of the Cellular response to cadmium ion pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IDNK, FRAT1, and MT2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to cadmium ion activity versus IDNK in HNSC (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IDNK →	-0.472	-0.129	<.001	.001	3	5
BRCA	FRAT1 →	-0.487	-0.434	.001	<.001	3	5
BRCA	MT2A →	+1.111	+0.305	<.001	.005	3	5
BRCA	ACTN1 →	+0.601	+0.430	.002	.001	3	5
UCEC	LOXL2 →	+0.825	+0.254	<.001	<.001	3	5
UCEC	CPA4 →	+0.794	+0.171	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071276 vs IDNK — HNSC

Explore this scatter interactively →