Cellular response to cadmium ion

Across TCGA cell cohorts, RNA activity of the Cellular response to cadmium ion pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRMT10B, AGFG1, and COA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRMT10B grouped by Cellular response to cadmium ion-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TRMT10B →	+0.620	+0.971	<.001	.009	3	4
SOFT_TISSUE	AGFG1 →	+0.864	+1.055	.002	.009	3	4
UPPER_AERODIGESTIVE_TRACT	COA1 →	-1.234	-1.324	.001	<.001	3	4
OVARY	WDFY1 →	+0.964	+1.004	.001	.001	3	4
URINARY_TRACT	BRAT1 →	-0.669	-1.104	<.001	.005	3	3
LARGE_INTESTINE	KIF25 →	+0.268	+0.625	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRMT10B by Cellular response to cadmium ion activity — OVARY

Explore this box plot interactively →