Cellular response to mechanical stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to mechanical stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LCP2, DPYD, and GIMAP8, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to mechanical stimulus activity versus LCP2 in GBM (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LCP2 →	+0.570	+0.086	<.001	<.001	3	9
GBM	DPYD →	+0.644	+0.064	<.001	<.001	3	8
GBM	GIMAP8 →	+0.617	+0.080	<.001	<.001	3	8
GBM	PPP1R18 →	+0.430	+0.085	<.001	<.001	3	8
GBM	TBC1D2B →	+0.430	+0.095	<.001	<.001	3	8
LSCC	DOCK4 →	+0.322	+0.040	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071260 vs LCP2 — GBM

Explore this scatter interactively →