Cellular response to mechanical stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to mechanical stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D2, SDC4, and TINAGL1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to mechanical stimulus activity versus TBC1D2 in LUNG_NSCLC_LUSC (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TBC1D2 →	+3.587	+0.395	.001	.007	2	8
LUNG_SCLC	SDC4 →	+2.462	+0.205	<.001	<.001	3	7
STOMACH	TINAGL1 →	+3.401	+0.254	.001	.004	3	7
LARGE_INTESTINE	SLC2A1 →	+2.541	+0.428	<.001	.002	3	7
LUNG_NSCLC_LUSC	ULBP2 →	+3.874	+0.390	<.001	.007	3	6
SKIN	AIFM1 →	-1.081	-0.417	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071260 vs TBC1D2 — LUNG_NSCLC_LUSC

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