Cellular response to electrical stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to electrical stimulus pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PALM, LPAR4, and KLHL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to electrical stimulus activity versus PALM in UCEC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PALM →	+1.116	+0.314	<.001	<.001	3	5
GBM	LPAR4 →	+0.711	+0.148	.008	.007	2	5
GBM	KLHL2 →	+0.389	+0.172	.003	.001	3	4
GBM	PPFIA2 →	+1.186	+0.178	.001	.006	3	4
BRCA	ABCC11 →	+1.533	+0.304	<.001	.002	3	3
GBM	GAD1 →	+1.550	+0.222	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071257 vs PALM — UCEC

Explore this scatter interactively →