Cellular response to electrical stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to electrical stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PALM_S116, PALM_S162, and PALM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to electrical stimulus activity versus PALM_S116 in UCEC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PALM_S116 →	+1.098	+0.466	<.001	<.001	3	5
UCEC	PALM_S162 →	+0.789	+0.339	<.001	<.001	3	4
GBM	PALM →	+0.733	+0.307	<.001	<.001	3	4
GBM	SEPTIN4_S117 →	+1.288	+0.263	<.001	<.001	3	3
PDAC	SLC9A1 →	+0.543	+0.221	<.001	<.001	3	3
PDAC	SLC9A1_S693 →	+0.468	+0.203	.005	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071257 vs PALM_S116 — UCEC

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