Cellular response to electrical stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to electrical stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF823, SMIM1, and CYP2R1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF823 grouped by Cellular response to electrical stimulus-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF823 →	-0.895	-2.050	.002	<.001	3	4
STOMACH	SMIM1 →	-1.680	-1.288	<.001	<.001	3	4
OVARY	CYP2R1 →	-1.040	-1.055	.003	.002	3	4
LUNG_NSCLC_LUAD	NMNAT1 →	-0.593	-0.894	.001	<.001	3	4
STOMACH	TRDMT1 →	+0.781	+1.415	.009	.002	3	4
BLOOD_Lymphoma	EXOSC3 →	-0.756	-1.971	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF823 by Cellular response to electrical stimulus activity — BLOOD_Lymphoma

Explore this box plot interactively →