Cellular response to electrical stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to electrical stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKL1, PELP1, and GAS6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to electrical stimulus activity versus CDKL1 in LIVER (Pearson r = -0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CDKL1 →	-1.920	-0.142	.003	.002	3	4
OVARY	PELP1 →	-1.125	-0.224	<.001	<.001	3	4
SOFT_TISSUE	GAS6 →	+3.147	+0.279	<.001	.003	3	4
LIVER	KLK5 →	+0.159	+0.122	<.001	<.001	3	3
SKIN	MARCHF3 →	+0.872	+0.208	.008	.009	3	3
SKIN	GOLGA8J →	+0.072	+0.320	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071257 vs CDKL1 — LIVER

Explore this scatter interactively →