Cellular response to arsenic-containing substance

Across TCGA patient cohorts, RNA activity of the Cellular response to arsenic-containing substance pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAD54L2_T1260, RTRAF, and SIPA1L2_S1244, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to arsenic-containing substance activity versus RAD54L2_T1260 in GBM (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RAD54L2_T1260 →	-0.392	-0.037	.004	<.001	3	4
GBM	RTRAF →	-0.327	-0.040	<.001	.002	3	4
CCRCC	SIPA1L2_S1244 →	-0.384	-0.054	<.001	<.001	3	4
GBM	YJU2 →	-0.268	-0.033	.001	.001	3	4
GBM	C1R →	+0.331	+0.023	.004	.005	2	5
GBM	DDX1 →	-0.197	-0.035	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071243 vs RAD54L2_T1260 — GBM

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