Cellular response to arsenic-containing substance

Across TCGA cell cohorts, RNA activity of the Cellular response to arsenic-containing substance pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTO1, GHITM, and VDAC2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to arsenic-containing substance activity versus GSTO1 in BLOOD_Lymphoma (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GSTO1 →	+3.133	+0.284	.001	<.001	3	8
OESOPHAGUS	GHITM →	+0.831	+0.302	<.001	<.001	3	6
BREAST	VDAC2 →	+0.848	+0.285	.002	.001	3	6
URINARY_TRACT	RTL6 →	+0.716	+0.307	<.001	<.001	3	5
BREAST	MRPS16 →	+0.960	+0.397	<.001	<.001	3	5
LUNG_NSCLC_LUSC	RNPEPL1 →	+1.095	+0.328	.004	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071243 vs GSTO1 — BLOOD_Lymphoma

Explore this scatter interactively →