Cellular response to ammonium ion

Across TCGA patient cohorts, RNA activity of the Cellular response to ammonium ion pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASS1, RDH10, and NIBAN2_S696, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to ammonium ion activity versus ASS1 in UCEC (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASS1 →	+1.019	+0.184	<.001	<.001	3	7
LUAD	RDH10 →	+0.685	+0.119	<.001	.006	3	7
UCEC	NIBAN2_S696 →	+0.675	+0.148	<.001	.001	3	5
PDAC	SCO2 →	+0.335	+0.130	<.001	<.001	3	5
CCRCC	CAMSAP3_S334 →	+0.605	+0.128	<.001	.002	3	5
UCEC	CLINT1 →	+0.227	+0.136	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071242 vs ASS1 — UCEC

Explore this scatter interactively →