Cellular response to ammonium ion

Across TCGA patient cohorts, RNA activity of the Cellular response to ammonium ion pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPS1, RPS4XP6, and RPS10P2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to ammonium ion activity versus CPS1 in LUAD (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CPS1 →	+2.774	+0.375	<.001	.001	3	5
BRCA	RPS4XP6 →	+0.812	+0.558	.005	<.001	3	4
LUAD	RPS10P2 →	+0.593	+0.427	.001	.003	2	4
LUAD	MARCHF11-AS1 →	+0.638	+0.494	.005	.003	3	3
LSCC	ADGRF1 →	+1.241	+0.762	.002	<.001	3	3
LSCC	MIR190A →	-0.683	-0.620	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071242 vs CPS1 — LUAD

Explore this scatter interactively →