Cellular response to L-leucine

Across TCGA patient cohorts, RNA activity of the Cellular response to L-leucine pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLPX, RPS2, and ANKRD44, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to L-leucine activity versus CLPX in OV (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CLPX →	-0.277	-0.052	<.001	<.001	3	7
HNSC	RPS2 →	-0.241	-0.087	<.001	<.001	3	7
HNSC	ANKRD44 →	+0.468	+0.093	<.001	<.001	3	7
UCEC	WAS →	+0.480	+0.065	.001	.001	3	7
UCEC	LCP1 →	+0.607	+0.072	<.001	<.001	3	7
OV	RPL12 →	-0.190	-0.050	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071233 vs CLPX — OV

Explore this scatter interactively →