Cellular response to L-leucine

Across TCGA patient cohorts, RNA activity of the Cellular response to L-leucine pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC15, CNEP1R1P1, and ACTG1P16, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to L-leucine activity versus DNAJC15 in HNSC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DNAJC15 →	-0.744	-0.431	<.001	.004	3	3
GBM	CNEP1R1P1 →	-0.162	-0.383	.002	.003	3	2
UCEC	ACTG1P16 →	-0.244	-0.440	.006	.001	3	2
CCRCC	DTX3 →	-0.500	-0.376	.002	.005	3	2
CCRCC	RNU6-640P →	-0.939	-0.787	<.001	<.001	3	2
CCRCC	RPS2P55 →	-0.396	-0.623	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071233 vs DNAJC15 — HNSC

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