Cellular response to L-leucine

Across TCGA cell cohorts, RNA activity of the Cellular response to L-leucine pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FZD6, PLS3, and PPP4R1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FZD6 grouped by Cellular response to L-leucine-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FZD6 →	+0.736	+0.241	.003	.001	3	4
LUNG_SCLC	PLS3 →	+2.962	+0.327	.003	.005	3	3
BONE	PPP4R1 →	+1.142	+1.931	.001	.001	3	3
BONE	C1GALT1 →	+2.248	+1.904	.004	.001	3	3
BONE	STBD1 →	+2.045	+1.872	.007	.002	3	3
BONE	ANKRD16 →	-1.049	-1.911	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FZD6 by Cellular response to L-leucine activity — OESOPHAGUS

Explore this box plot interactively →