Cellular response to L-leucine

Across TCGA cell cohorts, RNA activity of the Cellular response to L-leucine pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKRA, RAB35, and LRFN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKRA grouped by Cellular response to L-leucine-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRKRA →	-0.322	-0.077	.003	.005	3	6
SKIN	RAB35 →	+0.329	+0.076	<.001	.006	3	5
LIVER	LRFN1 →	-0.167	-0.085	.001	.004	3	4
BONE	EPB41L4A →	+0.212	+0.081	.001	.002	3	4
SOFT_TISSUE	USP7 →	+0.459	+0.141	<.001	.001	3	4
OVARY	GALNT7 →	+0.210	+0.074	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKRA by Cellular response to L-leucine activity — OESOPHAGUS

Explore this box plot interactively →