Cellular response to L-leucine

Across TCGA cell cohorts, RNA activity of the Cellular response to L-leucine pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2D7, IVNS1ABP, and HADHB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP2D7 grouped by Cellular response to L-leucine-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CYP2D7 →	+0.303	+1.431	<.001	<.001	3	3
STOMACH	IVNS1ABP →	-0.214	-0.378	.007	.003	3	3
CNS	HADHB →	+0.184	+1.046	.002	.001	3	3
CNS	SYT16 →	+0.404	+1.330	.005	<.001	3	3
STOMACH	USP16 →	+0.133	+0.391	.008	.001	3	3
OESOPHAGUS	CSNK1A1 →	-0.365	-1.283	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP2D7 by Cellular response to L-leucine activity — BLOOD_Leukemia

Explore this box plot interactively →