Cellular response to acid chemical

Across TCGA patient cohorts, RNA activity of the Cellular response to acid chemical pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NID1, PIK3CA, and DOCK4, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to acid chemical activity versus NID1 in TGCT (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	NID1 →	+1.664	+0.021	<.001	<.001	3	33
THYM	PIK3CA →	+1.140	+0.038	<.001	<.001	3	33
THYM	DOCK4 →	+1.281	+0.036	<.001	<.001	3	33
THYM	LATS1 →	+1.191	+0.036	<.001	<.001	3	33
THYM	HSPG2 →	+2.214	+0.046	<.001	<.001	3	33
THYM	LATS2 →	+1.412	+0.031	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071229 vs NID1 — TGCT

Explore this scatter interactively →