Cellular response to acid chemical

Across TCGA patient cohorts, RNA activity of the Cellular response to acid chemical pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DPYSL3, COPZ2, and RAB23, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to acid chemical activity versus DPYSL3 in COAD (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DPYSL3 →	+0.786	+0.026	<.001	<.001	3	9
OV	COPZ2 →	+0.680	+0.041	.002	.001	3	9
OV	RAB23 →	+0.364	+0.038	<.001	<.001	3	9
UCEC	ACTN1 →	+0.502	+0.059	<.001	<.001	3	8
HNSC	DAB2_S723 →	+0.818	+0.049	<.001	.003	3	8
CCRCC	EFEMP1 →	+0.755	+0.039	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071229 vs DPYSL3 — COAD

Explore this scatter interactively →