Cellular response to acid chemical

Across TCGA patient cohorts, RNA activity of the Cellular response to acid chemical pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA3, SRPX2, and CCN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to acid chemical activity versus ITGA3 in UCEC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ITGA3 →	+1.014	+0.130	.003	.003	3	6
LUAD	SRPX2 →	+0.651	+0.165	<.001	<.001	3	6
OV	CCN1 →	+1.010	+0.234	.001	<.001	3	5
OV	MFAP5 →	+1.644	+0.320	.002	.002	3	5
CCRCC	NRP2 →	+0.632	+0.116	.001	.004	3	5
LSCC	COL5A1 →	+0.835	+0.200	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071229 vs ITGA3 — UCEC

Explore this scatter interactively →