Cellular response to acid chemical

Across TCGA cell cohorts, RNA activity of the Cellular response to acid chemical pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DENND3, RASSF7, and BID, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DENND3 grouped by Cellular response to acid chemical-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DENND3 →	+1.408	+0.133	.008	.006	3	5
LIVER	RASSF7 →	+1.440	+0.377	.006	.002	3	4
OESOPHAGUS	BID →	+1.268	+0.174	.003	.006	2	5
CNS	CEP68 →	-0.404	-0.188	.003	.004	3	4
UPPER_AERODIGESTIVE_TRACT	AP5S1 →	+1.258	+0.194	<.001	.001	3	4
CNS	SNRPB2 →	+0.533	+0.212	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DENND3 by Cellular response to acid chemical activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →