Cellular response to muramyl dipeptide

Across TCGA patient cohorts, RNA activity of the Cellular response to muramyl dipeptide pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VIM, VIM_S214, and VIM_S47, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to muramyl dipeptide activity versus VIM in PDAC (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	VIM →	+0.625	+0.424	<.001	<.001	3	10
OV	VIM_S214 →	+1.113	+0.410	<.001	<.001	3	10
OV	VIM_S47 →	+0.876	+0.308	<.001	<.001	3	10
OV	VIM_S22 →	+0.914	+0.328	<.001	<.001	3	9
OV	VIM_S29 →	+1.413	+0.350	<.001	<.001	3	9
HNSC	VIM_S430 →	+0.708	+0.296	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071225 vs VIM — PDAC

Explore this scatter interactively →