Cellular response to muramyl dipeptide

Across TCGA cell cohorts, RNA activity of the Cellular response to muramyl dipeptide pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR81, GBF1, and OPTN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR81 grouped by Cellular response to muramyl dipeptide-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	WDR81 →	-0.590	-1.107	.009	.006	2	5
BLOOD_Lymphoma	GBF1 →	-0.625	-0.498	<.001	.001	3	4
BLOOD_Lymphoma	OPTN →	-3.769	-0.554	<.001	.005	3	4
BLOOD_Lymphoma	TRIM45 →	-1.657	-0.444	<.001	.002	3	4
OESOPHAGUS	HHAT →	-1.127	-0.806	<.001	.001	3	4
OESOPHAGUS	PNPLA8 →	-0.961	-1.261	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR81 by Cellular response to muramyl dipeptide activity — BLOOD_Leukemia

Explore this box plot interactively →