Cellular response to muramyl dipeptide

Across TCGA cell cohorts, RNA activity of the Cellular response to muramyl dipeptide pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDIK1L, COX4I1, and KCNJ12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDIK1L grouped by Cellular response to muramyl dipeptide-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PDIK1L →	-0.191	-0.124	.004	<.001	3	5
BONE	COX4I1 →	-0.242	-0.152	<.001	.001	3	5
LUNG_NSCLC_LUAD	KCNJ12 →	-0.149	-0.119	.002	.004	3	5
BREAST	CRK →	+0.177	+0.139	.002	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	NAA16 →	+0.172	+0.102	<.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	CDH1 →	-0.161	-0.149	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDIK1L by Cellular response to muramyl dipeptide activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →