Cellular response to muramyl dipeptide

Across TCGA cell cohorts, RNA activity of the Cellular response to muramyl dipeptide pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VIM, PMP22, and BSPRY, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to muramyl dipeptide activity versus VIM in URINARY_TRACT (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	VIM →	+7.372	+0.406	<.001	.001	2	13
BLOOD_Leukemia	PMP22 →	+1.930	+0.097	<.001	.004	3	9
BREAST	BSPRY →	-3.328	-0.304	<.001	<.001	2	8
LUNG_SCLC	DENND5A →	+0.478	+0.164	.009	.004	3	7
URINARY_TRACT	PRRG4 →	-2.102	-0.386	.001	.003	3	6
STOMACH	TMPRSS4 →	-3.680	-0.568	.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071225 vs VIM — URINARY_TRACT

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