Cellular response to peptidoglycan

Across TCGA patient cohorts, RNA activity of the Cellular response to peptidoglycan pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TREM2, RIPK2, and FCGR1A, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to peptidoglycan activity versus TREM2 in THYM (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	TREM2 →	+2.621	+0.106	<.001	<.001	3	29
KICH	RIPK2 →	+0.820	+0.066	.002	.001	3	23
THYM	FCGR1A →	+1.234	+0.093	<.001	<.001	3	22
SARC	TYROBP →	+1.370	+0.049	<.001	<.001	3	22
SCLC	TMIGD3 →	+1.329	+1.015	<.001	<.001	2	22
SCLC	FCGR2A →	+1.402	+1.344	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071224 vs TREM2 — THYM

Explore this scatter interactively →