Cellular response to peptidoglycan

Across TCGA patient cohorts, RNA activity of the Cellular response to peptidoglycan pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CASP4, STRN3_S229, and TYMP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to peptidoglycan activity versus CASP4 in HNSC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CASP4 →	+0.635	+0.149	<.001	<.001	3	5
LSCC	STRN3_S229 →	+0.346	+0.065	<.001	.008	3	4
LSCC	TYMP →	+0.635	+0.107	<.001	<.001	3	4
LUAD	CROCC_S1619 →	-1.224	-0.122	.002	.002	3	4
LUAD	FAM210B →	-0.637	-0.060	<.001	.001	3	4
LUAD	MYO1D →	-0.356	-0.060	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071224 vs CASP4 — HNSC

Explore this scatter interactively →