Cellular response to peptidoglycan

Across TCGA patient cohorts, RNA activity of the Cellular response to peptidoglycan pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL3, RIPK2, and BEX2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to peptidoglycan activity versus CXCL3 in LSCC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CXCL3 →	+0.673	+0.431	<.001	.001	3	6
CCRCC	RIPK2 →	+0.695	+0.970	<.001	<.001	3	6
LUAD	BEX2 →	-1.338	-0.436	<.001	.006	3	4
LUAD	IL1RN →	+0.668	+0.419	.003	.005	3	4
LUAD	SAMD9 →	+0.579	+0.396	<.001	.003	3	4
BRCA	S100A9 →	+1.478	+0.249	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071224 vs CXCL3 — LSCC

Explore this scatter interactively →