Cellular response to peptidoglycan

Across TCGA patient cohorts, RNA activity of the Cellular response to peptidoglycan pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIPK2, RIPK2_S363, and TCEAL4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to peptidoglycan activity versus RIPK2 in BRCA (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RIPK2 →	+0.412	+0.347	<.001	.001	3	5
LUAD	RIPK2_S363 →	+0.681	+0.729	<.001	<.001	2	6
BRCA	TCEAL4 →	-0.638	-0.428	<.001	<.001	3	4
UCEC	SH3D21_S452 →	+1.741	+1.725	<.001	<.001	3	3
LUAD	RAP1GAP_S515 →	-1.046	-0.567	<.001	<.001	3	3
PDAC	RIPK2_S393 →	+0.870	+0.859	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071224 vs RIPK2 — BRCA

Explore this scatter interactively →