Cellular response to peptidoglycan

Across TCGA cell cohorts, RNA activity of the Cellular response to peptidoglycan pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ETV6, PYGB, and CDKN1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ETV6 grouped by Cellular response to peptidoglycan-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ETV6 →	-0.818	-1.341	.001	<.001	3	5
SKIN	PYGB →	-1.480	-1.060	<.001	.002	2	5
SKIN	CDKN1A →	-2.535	-1.217	<.001	<.001	3	4
SKIN	EFCAB13 →	-0.658	-0.873	.002	.001	3	4
URINARY_TRACT	IL7 →	+1.256	+2.041	<.001	<.001	3	4
BLOOD_Myeloma	ARHGEF12 →	-1.326	-1.329	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ETV6 by Cellular response to peptidoglycan activity — STOMACH

Explore this box plot interactively →