Cellular response to biotic stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to biotic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, HCK, and TLR8, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to biotic stimulus activity versus CSF2RB in DLBC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	CSF2RB →	+2.061	+0.063	<.001	.001	3	34
SARC	HCK →	+2.083	+0.037	<.001	<.001	3	34
LAML	TLR8 →	+3.259	+0.077	<.001	<.001	3	34
LAML	LILRB1 →	+2.318	+0.068	<.001	<.001	3	34
LAML	LILRA1 →	+2.573	+0.073	<.001	<.001	3	34
SKCM	IL10RA →	+2.103	+0.044	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071216 vs CSF2RB — DLBC

Explore this scatter interactively →