Cellular response to biotic stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to biotic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3HAV1, KIAA1549L, and TMEM131L, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to biotic stimulus activity versus ZC3HAV1 in COAD (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZC3HAV1 →	+0.500	+0.160	.004	<.001	3	2
COAD	KIAA1549L →	+0.719	+0.185	.007	<.001	3	2
COAD	TMEM131L →	+0.540	+0.124	.005	.004	3	2
COAD	KCNS1 →	+0.174	+0.143	.001	.002	3	2
COAD	POM121L9P →	+0.250	+0.185	<.001	<.001	3	2
BRCA	MAP7D3 →	+1.390	+0.389	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071216 vs ZC3HAV1 — COAD

Explore this scatter interactively →