Cellular response to biotic stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to biotic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP3, KLHL5, and EXPH5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to biotic stimulus activity versus TJP3 in STOMACH (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TJP3 →	-3.225	-0.145	<.001	.003	3	5
URINARY_TRACT	KLHL5 →	+2.123	+0.347	.004	.001	3	4
URINARY_TRACT	EXPH5 →	-2.149	-0.414	.006	.001	3	4
URINARY_TRACT	CEP170 →	+2.320	+0.349	<.001	.005	3	4
URINARY_TRACT	RASEF →	-1.097	-0.308	.003	.002	2	5
URINARY_TRACT	TRMT10C →	-0.531	-0.268	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071216 vs TJP3 — STOMACH

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