Protein targeting to vacuole involved in autophagy

Across TCGA patient cohorts, RNA activity of the Protein targeting to vacuole involved in autophagy pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGT7, SQSTM1, and ZNF775-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein targeting to vacuole involved in autophagy activity versus GGT7 in GBM (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GGT7 →	-0.342	-0.440	<.001	.003	3	5
LSCC	SQSTM1 →	+0.652	+0.259	<.001	<.001	3	4
GBM	ZNF775-AS1 →	-0.420	-0.645	<.001	<.001	3	4
LSCC	AADAC →	+1.228	+0.228	.002	.007	3	4
LSCC	BLVRB →	+0.656	+0.180	<.001	.002	3	4
BRCA	CHST10 →	-0.756	-0.124	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071211 vs GGT7 — GBM

Explore this scatter interactively →