Protein targeting to vacuole involved in autophagy

Across TCGA cell cohorts, RNA activity of the Protein targeting to vacuole involved in autophagy pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAPA, SIPA1L3, and KIF1C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NAPA grouped by Protein targeting to vacuole involved in autophagy-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NAPA →	+1.134	+0.315	<.001	.009	2	4
STOMACH	SIPA1L3 →	+1.367	+0.368	.005	.001	3	3
LIVER	KIF1C →	+0.792	+0.363	<.001	.002	3	3
BLOOD_Leukemia	CBX8 →	+0.853	+1.284	<.001	<.001	3	3
LARGE_INTESTINE	ATAD1 →	-0.552	-0.640	.004	.008	3	3
UPPER_AERODIGESTIVE_TRACT	GKAP1 →	-1.171	-0.326	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NAPA by Protein targeting to vacuole involved in autophagy activity — STOMACH

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