Establishment of protein localization to chromatin

Across TCGA patient cohorts, RNA activity of the Establishment of protein localization to chromatin pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKRIP1, AKAP8L, and CDCA8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to chromatin activity versus PRKRIP1 in HNSC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRKRIP1 →	+0.282	+0.053	<.001	.004	3	7
LSCC	AKAP8L →	+0.171	+0.048	.003	<.001	3	7
LUAD	CDCA8 →	+0.850	+0.065	.004	<.001	2	7
BRCA	ERH →	+0.207	+0.036	.004	.003	3	6
LSCC	THOC1 →	+0.281	+0.061	<.001	.004	3	6
LSCC	CXorf56 →	+0.319	+0.055	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071169 vs PRKRIP1 — HNSC

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