Establishment of protein localization to chromatin

Across TCGA patient cohorts, RNA activity of the Establishment of protein localization to chromatin pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AURKA, EMP1, and MRC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to chromatin activity versus AURKA in GBM (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AURKA →	+0.595	+0.198	.003	.006	3	6
OV	EMP1 →	-0.801	-0.242	.004	.004	3	5
BRCA	MRC1 →	-0.951	-0.205	<.001	<.001	3	5
GBM	CDC25C →	+0.935	+0.320	<.001	<.001	3	5
GBM	DHFR →	+0.679	+0.304	<.001	<.001	3	5
COAD	PDLIM2 →	-0.292	-0.207	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071169 vs AURKA — GBM

Explore this scatter interactively →