Establishment of protein localization to chromatin

Across TCGA cell cohorts, RNA activity of the Establishment of protein localization to chromatin pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUNX2, RABAC1, and CFP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RUNX2 grouped by Establishment of protein localization to chromatin-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RUNX2 →	-1.368	-0.219	.006	.004	3	5
SOFT_TISSUE	RABAC1 →	-1.354	-0.248	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CFP →	-0.404	-0.354	<.001	.006	3	4
BLOOD_Myeloma	ARNTL →	-2.480	-0.428	.006	.003	3	4
LUNG_NSCLC_LUAD	ITPR1 →	-1.257	-0.218	.004	.006	3	4
SOFT_TISSUE	CD99L2 →	-0.845	-0.195	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RUNX2 by Establishment of protein localization to chromatin activity — LUNG_NSCLC_LUAD

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