Establishment of protein localization to chromatin

Across TCGA cell cohorts, RNA activity of the Establishment of protein localization to chromatin pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2B5, MBTD1, and TET3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to chromatin activity versus EIF2B5 in BLOOD_Leukemia (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EIF2B5 →	+0.400	+0.130	.003	.005	3	5
LIVER	MBTD1 →	+1.352	+0.351	<.001	.009	3	5
PANCREAS	TET3 →	+1.024	+0.207	<.001	<.001	3	5
BONE	SLC25A39 →	-1.352	-0.293	.001	.004	3	5
LUNG_NSCLC_LUAD	GID8 →	+0.501	+0.137	.002	<.001	3	5
OESOPHAGUS	LRRC45 →	+1.447	+0.186	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071169 vs EIF2B5 — BLOOD_Leukemia

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