Ribonucleoprotein complex localization

pathway activity — cross-omics
GO:0071166Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Ribonucleoprotein complex localization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, USP15_S229, and VCAN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVRPL5 →-0.195-0.061.007.00226
LUADUSP15_S229 →-0.580-0.044<.001<.00135
BRCAVCAN →+0.819+0.048<.001<.00135
BRCACAB39L →+0.616+0.035.001.00135
GBMARFGAP3 →-0.305-0.046<.001.00235
LUADRPL3 →-0.372-0.046<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration