Ribonucleoprotein complex localization

pathway activity — cross-omics
GO:0071166Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Ribonucleoprotein complex localization pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DMD, NINJ2, and ACTA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCDMD →-0.617-0.854.005.00425
OVNINJ2 →-0.850-0.692<.001<.00134
BRCAACTA2 →-0.786-0.391.005.00725
BRCANUP210 →+0.589+0.374.001.00834
BRCATAGLN →-0.711-0.414.003.00925
BRCAGREM2 →-0.716-0.568<.001.00334
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration